In the labs first foray into neurodegeneration, we report that alterations in mitochondrial calcium exchange proceed histopathology and cognitive decline in multiple Alzheimer’s disease (AD) models. The Pooja Jadiya led study also showed that these same mitochondrial alterations occur in the brains of patients diagnosed with sporadic AD. Her work has garnered numerous awards and been featured by numerous news outlets.
Jadiya P, Kolmetzky DW, Tomar D, Meco AD, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, Elrod JW. Impaired mitochondrial calcium efflux contributes to Alzheimer’s disease progression. Nat Commun. 2019 Aug 29