Jonathan published his thesis work defining a how MCUB alters the stoichiometry of the uniporter to modulate mitochondrial calcium uptake during stress.
The new research, published in the journal Circulation, identifies MCUB as a promising new target for the treatment of conditions that feature calcium overload and cell death – conditions that include heart failure, heart attack, stroke, and neurodegeneration.
“MCUB fine-tunes calcium uptake by mitochondria in injured heart tissue, in an attempt to limit calcium overload, which is a major contributor to cell death, particularly following a heart attack,” explained John W. Elrod, PhD, Associate Professor in the Center for Translational Medicine at the Temple University Lewis Katz School of Medicine and senior investigator on the new study.
Lambert JP, Luongo TS, Tomar D, Jadiya P, Gao E, Zhang X, Lucchese AM, Kolmetzky DW, Shah NS, Elrod JW. MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress. Circulation. 2019 Sep 19. 10.1161/CIRCULATIONAHA.118.037968