Cohen's Commentary in Cell Calcium
In the July issue of Cell Calcium, Henry discussed Israel Sekler’s recent observation that PDE2-dependent regulation of NCLX is essential for neuronal survival and contextualized these findings within existing literature.
HENRY COHEN AWARDED NIH MD/PHD FELLOWSHIP
Henry received a Ruth L. Kirschstein National Research Service Award (F30 MD/PhD Fellowship) for his project “The Role of MICU3 in Alzheimer’s Disease Pathogenesis.
Excellent work Henry!
Jadiya published in iScience
Check out the latest from the Elrod lab in iScience! First author and former Elrod Lab postdoc Pooja Jadiya published yet another excellent paper titled “Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline”. Congratulations Pooja!
Check out the paper here.
Andrew Gibb Awarded CDA
Andrew was awarded the American Heart Association Career Development Award (CDA) to transition to independent faculty to study the effects of glutamine metabolism in cardiac pathological remodeling and fibrosis.
Gibb published in JMCC
Andrew’s paper titled “Glutamine uptake and catabolism is required for myofibroblast formation and persistence” was published in the Journal of Molecular and Cellular Cardiology. This study delves deeper into his work that was published in Circulation in May 2022. This study concludes that, “glutaminolysis as necessary for myofibroblast formation and persistence, providing substantial rationale to evaluate several new therapeutic targets to treat cardiac fibrosis”.
Read Andrew’s newest publication here.
Garbincius scored the cover of the June issue of JMCC
Joanne’s work titled “Enhanced NCLX-dependent mitochondrial Ca2+ efflux attenuates pathological remodeling in heart failure” published in JMCC. Some highlights from the study: NCLX mediates mitochondrial calcium efflux, NCLX limits mito calcium accumulation upon hypertrophic stimulation as well as oxidative metabolism and protein synthesis during hypertrophy.
Read it here
And we scored the cover of the June issue in JMCC!
Dr. John Elrod Named Director of the Cardiovascular Research Center
Congratulations are in order for Dr. Elrod as he was named Director of the Cardiovascular Research Center (CVRC)! John has been taking Temple by storm with top notch publications in high impact journals such as Nature, Nature Communications, and JMCC… just to name a few. John has built a highly collaborative and innovative lab and plans on bringing this culture to the CVRC at large. Furthermore, John has an extraordinary record of mentoring students and postdoctoral fellows who have since had successful careers in academia and in industry. This was also reflected when he won the Lewis Katz School of Medicine Educational Experience Award for 2022. Great things are to come to the CVRC with John at the helm!
Congratulations John, this was well deserved!
P.S. No, John did not write this about himself.
Gibb's research letter published in Circulation
Senior post-doc, Dr. Andrew Gibb’s newest work, a research letter, titled “Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure” was published in Circulation. This study identifies “glutaminolysis as a critical mediator of myofibroblast persistence in a murine model of HF and in CFs isolated directly from failing human hearts”.
Read the research letter here
The review of a life time: Garbincius publishes a monster review for APS
Dr. Joanne Garbincius published a monster review in APS simply titled “Mitochondrial calcium exchange in physiology and disease”. This work highlights everything that researchers in the field have discovered thus far on the subject of mitochondrial calcium exchange in physiology and in disease.
Check out the 101 page review in APS!
Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
Dive into Andrew’s OMICs study defining changes in the metabolome and transcriptome in a model of HFpEF, in the August Issue of JACC: Basic to Translational Science.
The issue included a commentary by the McKinsey lab, “Cat-apulting Toward a Molecular Understanding of HFpEF”.
News portals highlighting the work:
Review published in Acta Neuropathologica Communications
Pooja and Joanne teamed up to write an extensive review of mitochondrial and metabolic dysfunction in neurodegenerative disease development and progression, “Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling” published in the July issue of Acta Neuropathologica Communications (https://doi.org/10.1186/s40478-021-01224-4).
Garbincius and Elrod Commentary published in circulation research
Joanne and John published a commentary on the controversies of mitochondrial calcium content in heart disease entitled, “Is the failing heart starved of mitochondrial calcium?” published in the April 16th issue of Circulation Research (PMID: 33856917).
Michael Lazaropoulos Awarded NIH MD/PhD Fellowship
Michael received a Ruth L. Kirschstein National Research Service Award (F30 MD/PhD Fellowship) for his project “The Role of Acetyl-CoA Metabolism in Epigenetic Regulation of Myofibroblast Differentiation”. Congrats Mike!
Pooja Jadiya Awarded K99
Pooja Jadiya was awarded an NIH Pathway to Independence Award (K99/R00) from the National Institute on Aging (NIA) to enable her transition to independent faculty. The project is focused on “The role of mitochondrial calcium uptake in Alzheimer's disease”.
Review published in Circulation Research
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Andrew and Michael’s review article titled “Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation” was published in the July 17th issue of Circulation Research (PMID: 32673537).
Review published in the Journal of Molecular and Cellular Cardiology
Joanne’s review article with lab alumnus Tim Luongo, titled “The debate continues - What is the role of MCU and mitochondrial calcium uptake in the heart?” (PMID:32353353) was published in the June 2020 issue of Journal of Molecular and Cellular Cardiology as part of a Special Issue, Unsolved mysteries and controversies of mitochondria in the heart.
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Dhanendra Tomar awarded K99
Dhanendra Tomar was awarded an NIH Pathway to Independence Award (K99/R00) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to enable his transition to independent faculty. Congrats DT!
Joanne Garbincius Awarded Postdoctoral Fellowship
Joanne was awarded an NIH F32 Ruth L. Kirschstein NRSA Postdoctoral Fellowship for her project on “Molecular Modulation of the Mitochondrial Na+/Ca2+ Exchanger as a novel therapeutic target for heart failure”. Congrats Joanne!
COMMENTARY published in Expert Opinions on Therapeutic Potential OF TARGETING MCUB
Jonathan and Emma’s review article titled “ MCUB and mitochondrial calcium uptake - modeling, function, and therapeutic potential” was published in Expert Opinions on Therapeutic Potential. (PMID: 32093523)
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