Garbincius et al. have a hot new publication in Nature Metabolism!

In the Elrod Lab’s newest publication featured in Nature Metabolism, “TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux", discovers a novel regulator of NCLX. Our research shows that TMEM65, a mitochondrial protein with previously unknown function, as a critical regulator of NCLX. By removing TMEM65, calcium builds up in mitochondria, confirming its essential role in supporting NCLX activity. The next steps for the team: explore TMEM65 as potential therapeutic target.

It is exciting to share that the Elrod Lab is the FIRST group of researchers to characterize the interaction of TMEM65 with NCLX in the mitochondria!

This ground breaking study is featured in Nature Metabolism News &Views, as well as featured in Recent Katz Research on the homepage of the Lewis Katz School of Medicine.