The lab regularly uses and generates new mutant mouse models for conditional overexpression or ablation of a given gene . These models allow causative testing to see if a gene really does alter the progression of disease in the intact animal.  These studies are made possible by an outstanding transgenic core facility at Temple Fox Chase Cancer Center.  The use of animal models allows us to assess the translational potential of a given therapy and is central to examining the likelihood of how a therapy may impact human disease.